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All medicines stimulated dose-connected locomotion in mice, and eutylone was most potent and efficacious in this regard (ED50 = ~two mg/kg, s.c.). Our success display that eutylone can be a hybrid transporter compound with uptake inhibition Homes at DAT and NET, but substrate activity at SERT. The effects of eutylone are similar to People made by pentylone, which implies that eutylone will exhibit abuse liability and pose risks for psychostimulant facet-results in human consumers.